The JIP3 scaffold protein UNC-16 regulates RAB-5 dependent membrane trafficking atC. eleganssynapses
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چکیده
منابع مشابه
UNC-16/JIP3 regulates early events in synaptic vesicle protein trafficking via LRK-1/LRRK2 and AP complexes
JIP3/UNC-16/dSYD is a MAPK-scaffolding protein with roles in protein trafficking. We show that it is present on the Golgi and is necessary for the polarized distribution of synaptic vesicle proteins (SVPs) and dendritic proteins in neurons. UNC-16 excludes Golgi enzymes from SVP transport carriers and facilitates inclusion of specific SVPs into the same transport carrier. The SVP trafficking ro...
متن کاملUNC-16, a JNK-Signaling Scaffold Protein, Regulates Vesicle Transport in C. elegans
Transport of synaptic components is a regulated process. Loss-of-function mutations in the C. elegans unc-16 gene result in the mislocalization of synaptic vesicle and glutamate receptor markers. unc-16 encodes a homolog of mouse JSAP1/JIP3 and Drosophila Sunday Driver. Like JSAP1/JIP3, UNC-16 physically interacts with JNK and JNK kinases. Deletion mutations in Caenorhabditis elegans JNK and JN...
متن کاملTBC-2 Regulates RAB-5/RAB-7-mediated Endosomal Trafficking in Caenorhabditis elegans
During endosome maturation the early endosomal Rab5 GTPase is replaced with the late endosomal Rab7 GTPase. It has been proposed that active Rab5 can recruit and activate Rab7, which in turn could inactivate and remove Rab5. However, many of the Rab5 and Rab7 regulators that mediate endosome maturation are not known. Here, we identify Caenorhabditis elegans TBC-2, a conserved putative Rab GTPas...
متن کاملAn organelle gatekeeper function for Caenorhabditis elegans UNC-16 (JIP3) at the axon initial segment.
Neurons must cope with extreme membrane trafficking demands to produce axons with organelle compositions that differ dramatically from those of the cell soma and dendrites; however, the mechanism by which they accomplish this is not understood. Here we use electron microscopy and quantitative imaging of tagged organelles to show that Caenorhabditis elegans axons lacking UNC-16 (JIP3/Sunday Driv...
متن کاملUNC-16/JIP3/sunday driver: a new cop on the organelle highway.
In this commentary, Qun Zheng and Michael L. Nonet examine Edwards et al.’s article in which they provide evidence for a domain in invertebrate neurons similar to the vertebrate axonal initial segment that serves to restrict certain organelles from entering the axonal compartment. In their article published in this month’s GENETICS, Edwards et al. (2013) implicate the UNC-16/JIP3/SYD as a criti...
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ژورنال
عنوان ژورنال: Developmental Neurobiology
سال: 2009
ISSN: 1932-8451,1932-846X
DOI: 10.1002/dneu.20690