The JIP3 scaffold protein UNC-16 regulates RAB-5 dependent membrane trafficking atC. eleganssynapses

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UNC-16/JIP3 regulates early events in synaptic vesicle protein trafficking via LRK-1/LRRK2 and AP complexes

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Neurons must cope with extreme membrane trafficking demands to produce axons with organelle compositions that differ dramatically from those of the cell soma and dendrites; however, the mechanism by which they accomplish this is not understood. Here we use electron microscopy and quantitative imaging of tagged organelles to show that Caenorhabditis elegans axons lacking UNC-16 (JIP3/Sunday Driv...

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ژورنال

عنوان ژورنال: Developmental Neurobiology

سال: 2009

ISSN: 1932-8451,1932-846X

DOI: 10.1002/dneu.20690